A decoy seems to exist in the president's May 2026 medical report.
It is the "AI-enhanced electrocardiogram" (AI-EKG) —
an utterly worthless test — that took the place of an extraordinarily useful
test: the standard 12-lead EKG.
But if the AI-EKG was a decoy, it backfired, because it
ultimately can be interpreted as substantial evidence that the Trump has amyloidosis.
EKG and ECG are equivalent. Throughout this website, EKG is used.
AI-EKG chronology and results
- Oct. 1, 2025 — The president's physician reports:
"His cardiac age — a validated measure of cardiovascular vitality via
ECG — was found to be approximately 14 years younger than his chronological age"
MORE.
- Jan. 1, 2026 — The Wall Street Journal reports:
"The White House provided the Journal with a summary of a
Mayo Clinic AI-assisted analysis of Trump's electrocardiogram
that estimated the president's cardiac age to be that of a 65-year-old"
1.
- May 29, 2026 — The president's medical report
states: An "AI-enhanced electrocardiogram (ECG) analysis estimated his cardiac age,
to be approximately 14 years younger than his chronological age"
MORE.
Why the AI-EKG might be a decoy
- Because of its name, the AI-EKG camouflaged the absence of the standard EKG.
- The standard EKG is an omission from the May 2026 report
MORE.
- The name "AI-enhanced EKG" is misleading. It suggests that it can do more than a standard
EKG, but exactly the opposite is emphatically true. A giant information loss occurred
when the AI-EKG displaced Trump's standard EKG.
- The name "AI-enhanced EKG" is incorrect. It is an umbrella term that
encompasses at least six distinct subsystems
2
3.
Trump's report included the results of only one of the subsystems, the AI-EKG-age.
- The AI-EKG-age subsystem calculates a "cardiac age" number for the patient.
- There is also an AI-EKG-amyloid subsystem that calculates a probability that the patient
has amyloidosis.
- It is likely that Trump had an AI-EKG-amyloid test, but its result was not publicly reported.
I have therefore listed it as an omission in the May 2026 report
MORE.
- The May 2026 report misrepresents the output of the AI-EKG-age in multiple ways:
- It erroneously claimed the AI-EKG-age measures "cardiovascular vitality."
- It erroneously claimed the AI-EKG-age assessment of vitality was "validated." (Doubling-down, it appears.)
- The prognostic value of the cardiac age number has never been validated in octogenarians.
- It failed to mention that the AI-EKG-age is not FDA-approved
4.
- It failed to adequately name the test, not even saying it was from the Mayo Clinic.
- It provided no pointers that would aid a reader in interpreting the result.
- It overstated the positivity of Trump's result, letting the user make the
obvious (and incorrect) assumption that the "cardiac age"
result could be simply interpreted as a linear age, when in fact the relation
to chronological age is not linear at older ages.
- The AI-EKG-age could be a decoy in time, too. The test was performed before October 2025, yet it is
reported in an official document dated May 2026 without saying whether the printed result is from
pre-October or some later time.
- That is sloppy and confusing.
- The undated AI-EKG-age result is therefore listed as an ambiguity in the May 2026
report
MORE.
The information loss
The AI-EKG-age reported for the president does only one
thing: calculate a "cardiac age" for the patient. One lousy number.
Compare that to the amount of information available in a standard 12-lead EKG...
I have two EKG textbooks from the 1980s: one takes 496 pages to say what the
standard EKG can show
5
and the other takes 621 pages
6.
As a specific example, by producing just a "cardiac age" it is impossible
for the AI-EKG-age to say anything at all about amyloidosis.
By contrast, the standard 12-lead EKG
can show multiple different signs of amyloidosis.
Cynically, therefore, substituting the AI-EKG-age for the standard EKG suppresses
any and all specific abnormalities that the standard EKG might have disclosed.
The AI-EKG-age result is not "cardiovascular vitality"
My readings in the medical literature (see references below) failed to explain why the
May 2026 report labeled the output of the AI-EKG-age subsystem as "cardiovascular vitality."
That is a nice-sounding phrase, which carries a certain connotation, but
nowhere is it mentioned in any of the Mayo Clinic's publications that I reviewed.
And that is just what one would expect. The notion of "cardiovascular vitality"
does not exist in day-to-day clinical medicine. Cardiology excels at quantifying several aspects of
how the heart performs, but there is no accepted way to combine them, and there is
no combination so brazen to label itself as "vitality."
The Mayo researchers call it "a biomarker of age"
7.
The AI-EKG-age result is overstated
Trump's result sounds impressive, but as the image below shows 8, the AI system awards a 65 year old cardiac age to a substantial fraction of 79 year olds (indicated by the black dot). In fact, it looks like the average cardiac age given to 79 year olds is about 69 — 10 years younger than Trump's age at the time of the test.
Clearly, the AI system is less accurate in older patients, and this alone should give pause about attaching a meaning to Trump's AI-EKG-age result.
AI age predictions vs. chronological age. Straight line shows where the two ages would be identical. Each of the thousands of test patients contributes to the dots. Black dot indicates President Trump's position: his chronological age is 79 and his AI estimated cardiac age is 65.
From
8.
Trump's AI-EKG-age result is 100% useless
The AI-estimated age for Trump's heart has no firm medical significance. In other words, it may sound significant to say that his heart has similarities to a 65 year old's, but there is no evidence to suggest that the similarities make any difference in how the heart will behave over time in the real world.
The Mayo AI-EKG-age subsystem was trained by feeding it hundreds of thousands of electrocardiograms where the age of the patient was known. That's all there was. The system got no data on how long the patients lived afterwards and it didn't know how sick the patients were at the time of the electrocardiogram.
So it's a pretty blind system, and that's the first reason it's useless.
The Mayo team performed a later study in much younger patients than Trump (average age 54) and found that an AI-estimated age younger than the chronological age conferred no survival benefit when compared against patients who had an AI-estimated-age close to their chronological age 7.
Survival according to the gap between AI predicted heart age and chronological age. Survival is better when the lines are closer to the top. Bottom two lines show poorer survival when the AI predicted heart age is higher than the chronological age (one line for somewhat higher and a worse line for much higher). Three lines cluster at the top and are statistically the same. These three lines are for patients whose AI estimate was the same, somewhat lower, or much lower than their chronological age, Trump included.
Figure is from
7.
So these are the second and third reasons the system is useless: no prognostic testing
in patients of Trump's age, and even if we extrapolate the testing in younger patients,
there is no news for Trump except that he's average.
The fourth reason the result is useless is that it leads to no actionable steps.
If a patient's heart reads out as excessively old, what can be done about that?
The patient cannot be made younger!
Perhaps in the normal world a cardiologist might run a slew of tests to try to find the
reason(s) the heart is reading out as old, but Trump is already getting those tests,
so doing the AI-EKG-age adds zero.
Speculation: For this last reason, especially, it is likely that the real point of getting Mayo's
AI-EKG-age was not to get the age reading, but to get the readings from the other
subsystems in the Mayo AI-EKG dashboard... primarily the AI-EKG-amyloid that
detects early amyloidosis.
The AI-EKG-age suggests Trump has amyloidosis (Speculation #1)
With apologies, this is a rather complicated bit of speculative reasoning, written only
secondarily for laypersons, most of whom will probably want to skip it.
- There has been little published research on how readings from the
standard electrocardiogram (the kind that was invented in 1911) change with age.
It has been noted that the "R-wave height" increases with age
9.
An idealized single heartbeat as it appears on an electrocardiogram. The tallest spike is called the "R wave" and its height has significance.
- Longstanding hypertension increases the height of R-waves.
- The builders of the Mayo AI-EKG-age subsystem identified hypertension as a
factor causing their software to label a person's cardiac age as older than their
chronological age
8.
- From all the above, it is reasonable to conclude that taller R-waves is a significant
factor in leading the AI-EKG-age subsystem to label a heart as old. Conversely,
but equivalently, shorter R-waves will lead the software to label a heart as young.
- The AI-EKG-age subsystem was trained on a group of 775,000 patients
7 in whom approximately half had hypertension
8a
10a.
These patients may be expected to have a higher than normal R-wave height, and there will be more of them among older patients in the training group.
Reasonably, this would lead the software to strongly associate tall R-waves with older hearts.
- Lower-than-normal R-wave height is an electrocardiographic hallmark of
cardiac amyloidosis
11,
which tends to be a disease of older people.
- From 2000 to 2019 the Mayo Clinic saw only 2541 patients with cardiac amyloidosis
12.
So even if every one of those cases has been used to train AI-EKG-age (an impossibility),
that would only be 0.3% of the training group.
This small percentage of short R-waves in old hearts in the training cases
is going to be swamped by the very large percentage of training cases with
tall R-waves in older hearts.
- Thus, the sofware will probably read short R-waves as an indicator of young age,
so that amyloidosis patients are consistently rated as having younger hearts than
their chronological age.
Therefore, if this is all true, then the lower AI-estimated-age for Trump is
exactly what would be expected if he had cardiac amyloidosis. The lower
AI-estimated age is actually evidence for Trump having cardiac amyloidosis.
I wouldn't take this conclusion to the bank, but I think at this point the onus is on the
Mayo people to prove that amyloidosis does not cause a systematic error in their
AI-EKG-age subsystem.
The AI-EKG-age suggests Trump has amyloidosis (Speculation #2)
The AI-EKG is available only from the Mayo Clinic because it is still experimental.
So why in the world would the White House go to the trouble of asking for the test?
A potential answer, as hypothesized earlier, is that the Mayo AI-EKG system has six (or more)
subsystems, and that the president's physician was interested in other subsystems
more than the AI-EKG-age subsystem.
This multiplicity of subsystems is easily seen in a snapshot of the Mayo
"AI-EKG dashboard" that collects results from the multiple subsystems.
This screen grab from
2 shows the Mayo AI dashboard,
which includes separate readouts for multiple different parameters. Amyloidosis risk
is one of those parameters, although it is not shown in this example.
(The amyloidosis readout is shown, however, in
3.)
This dashboard shows five readouts for one patient, and shows how probabilities
and calculations have changed for that patient over several years.
Performing the AI-EKG-age suggests Trump has amyloidosis if one accepts that his medical team
was actually interested in the AI-EKG-amyloid, the subsystem that calculates
the patient's probability of amyloidosis by analyzing the standard EKG.
The Mayo Clinic already has considerable experience with the AI-EKG-amyloid
subsystem, having enrolled more than 20,000 subjects in a clinical trial
before Trump's EKG was analyzed
13.
Why the AI-EKG-amyloid could be so helpful
The AI-EKG-amyloid system could be extremely useful in Trump's case.
The White House has Trump's standard EKGs on file back to 2018 (if not earlier)
so they could have fed them all at once to Mayo, which could then plot how
the probability of amyloidosis changed over the years, as in the
made-up example below.
This is not Trump's results, but a made-up example of how the Mayo AI-EKG-amyloid subsystem
could be useful in a patient like him.
It shows that the subsystem rated the patient's 2021 EKG to have a zero chance of indicating
amyloidosis, whereas the patient's 2024 EKG is 80% likely to be indicating amyloidosis.
Mayo researchers say that their AI-EKG-amyloid subsystem has, in some patients,
provided indications of amyloidosis years before anything else made them suspicious
2.
If a physician saw this type of plot, it would more than justify aggressive testing
for amyloidosis, which translates to a biopsy analysis (probably not, for the president,
unless recent surgical samples are on file) or
a TcPYP nuclear scan of the heart (takes hours).
Conclusion
From a public relations standpoint, the AI-EKG-age brought multiple benefits.
It enabled suppression of whatever abnormalities were on the standard
12-lead EKG and it helped paint a rosy picture of Trump's cardiac health,
regardless of its actual state.
If the White House came clean about the circumstances related to the AI-EKG,
perhaps an innocent truth behind all this would be disclosed, but based on
the information that is public now, and the information in the scientific literature
(which I cannot claimed to have scrutinized to the maximum possible degree), I
can think of no reason to include the AI-EKG-age in Trump's medical reports
other than public relations.
Such a conclusion has several weaknesses.
My reconstruction of these motivations is necessarily subjective.
Various areas on this page are marked as speculation.
And perhaps I have missed a reference or two from the literature
or have been too narrow in clinical reasoning.
If so, please let me know and I will correct and apologize.
But there is much here that is on firm ground, enough to warrant a "decoy" hypothesis.
Finally, there is the co-existence of the AI-EKG-amyloid with the AI-EKG-age at the
Mayo Clinic. The coincidence is absolutely arresting. It equals the famous coincidence
in the movie Casablanca: "Of all the gin joints, in all the towns,
in all the world, she walks into mine." But here, of all the experimental, unapproved
diagnostic tests being developed in all of medical science, in all the world,
Trump's EKG walks into the Mayo Clinic's
AI-EKG joint, where testing for amyloidosis is the specialty of the house.
The fundamental things apply.