Bernie Sanders: Annotated Medical Reports (2020)


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* Renal function? * Arrhymias in hospital? * STEMI or NSTEMI? ***** Complete revascularization??????
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1.1
The Attending Physician to Congress is a
1.2

"MACP" stands for "Master of the American College of Physicians. This is a prestigious standing awarded to only the most senior and accomplished internists.

It it unusual for physicians to list only their academic rank ("professor"), without listing their institution. Dr. Monahan was formerly Chairman of the Department of Medicine at the Uniformed Services University School of Medicine (the military medical school, in Bethesda, Maryland).

Dr. Monahan studiously avoids giving his military rank (rear admiral) here and in his signature block.

1.3 December 28, 2019
Is approximately 3 months after the heart attack. This is timely. Any earlier would not have allowed the clinical condition to settle down. However, the first six months after stent placement carry the highest risk for complications, taking us to April 1, 2020.

SHOULD HE GET A STRESS TEST THEN?

1.4 The Honorable Bernard Sanders
United States Senate
3.3 Dirksen Senate Office Building
Washington DC 20510
1.5 Dear Senator Sanders:

The letter is addressed to the patient. The physician, therefore, could have provided all of the patient's medical information without violating privacy. But because the letter withholds medical information that a physician would clearly provide in such a letter, it is apparent that the patient influenced the content of the letter.

He is writing to the patient. The physician is therefore free to write anything and everything (i.e. no privacy concerns). The patient can then decide whether to release the letter. So there must have been an agreement up front on what the physician would write.

1.6 This letter summarizes your general health history and current medical evaluation prepared at your request.

Here the physician says only that the patient requested the letter, but does not say that the patient left him (the physician) free to determine the contents of the letter.

1.7 My offlce has served as your physician for the past 29 years.
An office can't serve as a physician. Only a human can be a physician.
1.8 I am certified by the American Board of Internal Medicine and Internal Medicine, Hematology, and Medical Oncology.
Typo: "and Internal Medicine" should be "in Internal Medicine"
1.9 Your most recent physical examination was conducted on December 19, 2019 when you were 78 years old, 6 feet 0 inches tall, and weighed 174 pounds.
1.10 Your general physical examination was normal including a blood pressure of 102/56 mmHg, and pulse of 62 beats/min.

Using the word "general" to describe the physical examination is potentially a very large weasel word. It can mean that detailed examination of various organ systems -- the heart and the neurological system, for example -- were perfunctory or non-existent. Did the physician even examine the heart or the neurological system? We have no way of knowing. A more likely weasel maneuver, if we make the safe assumption that the physician is competent, is that detailed organ-specific examinations were made, but results from those examinations are excluded from this report because they are not part of the "general" physical examination.

To say the exam (however extensive it may have been) was "normal" is insufficiently detailed for a patient who had a heart attack just 8 weeks earlier. As an extreme example, if the physician examined only the fingernails, then saying the "physical examination was normal" is worthless. Also note that the physician felt compelled in sentence __ to reveal to the patient the values for age, height, and weight -- all of which are completely obvious to the patient -- but did not disclose important parameters which the patient cannot ascertain for himself, including assessments of cardiac gallops, cardiac filling pressures, fluid in the lungs, hypertensive damage to retinal arteries, and on and on.

A physical examination also includes taking a history, but this one doesn't. The letter does not even state whether this was the first hint of coronary disease. Perhaps the senator had a history of stable angina (or angina on a stress test) and did not receive treatment for it (see below) other than low-dose aspiring. We don't know. Perhaps the senator had previous heart attacks that were untreated (this is very common). The letter omits any mention of the vital historical questions that must be asked of heart attack survivors:

A thorough examination would certainly not have been normal. A 78-year-old man is guaranteed to have an enlarged prostate gland.

1.11 Recent comprehensive laboratory test results indicated your complete blood count, vitamin D level, and thyroid function panel were normal.
1.12 Your fasting glucose was 84 mg/dL.

This is not the preferred way to assess the presence or absence of diabetes. Had the physician truly been addressing this [important] point, he would have checked a hemoglobin A1c level, because it reports the average blood sugar level for the past three months. The fasting glucose reports it for only an instant in time.

1.13 Your total cholesterol was 117mg/dL, HDL cholesterol was 32mg/dL, and LDL cholesterol was 58 mg/dL.

Nice. (HDL a little low) Plaque regression?

1.14 Your electrocardiogram demonstrated normal sinus rhythm.

This is one of the most egregious statements in the letter. Any medical or nursing student who reported an EKG with only this one sentence would be chastised, *especially* when the patient recently had a heart attack. Were there Q waves? T wave abnormalities? In what coronary territories? Was there poor R wave progression? Left ventricular hypertrophy? Left bundle branch block or other conduction delays? The physician is a professor of medicine. It is inconceivable that he does not know the importance of these elements for diagnosis and prognosis, and it is inconceivable that he would fail in an honest report to characterize these elements in some way.

1.15 Over the years, you have been treated for medical conditions including

The letter reports only conditions for which he has been treated. This is not forthcoming, in two ways.
  1. He may have other unmentioned conditions that he has elected not to treat, of which prostate cancer would be a prime example.
  2. He may have two conditions that both have the same treatment, but discloses only the one he is being "treated for." Example: heart attack survivors are treated with aspirin, but so are many stroke survivors as well as many people who are at substantial risk for stroke and want to prevent it. Thus, given that Senator Sanders is being "treated for" his heart attack with aspirin, the letter does not rule out the possibility of stroke or stroke risk.

Was he really never treated for hypertension before his heart attack? It is rare for 78 year old men to be normotensive. (He is now taking the anti-hypertensive medication lisinopril

He has multiple risk factors for coronary artery disease: Gout, Hypercholesterolemia, Male sex, and Age.
1.15a gout, article
1.15b hypercholesterolemia,
1.15c diverticulitis,
1.15d hypothyroidism,
1.15e laryngitis secondary to esophageal reflux,

His history of esophageal reflux increases his risk for sleep apnea.

1.15f lumbar strain,
1.15g and complete removal of superficial skin lesions.

"Superficial skin lesions" is too vague to be a useful medical phrase, as it could span the gamut from simple warts (easy) to malignant melanoma (bad). Why did the physician not simply name the types of lesions? This is an example of deliberate obfuscation by the physician. Senator Sanders had a basal cell carcinoma removed from his cheeck in 2016. Furthermore, the phrase "complete removal" adds a pall to the possibilities, because no one -- especially a medical oncologist like the physician writing this letter -- really cares if a wart or a basal cell carcinoma undergoes "complete removal." Did Senator Sanders have a superficial malignant melanoma?

1.16 Your colorectal cancer screening is up to date.
1.17 Your past surgical history consists of repair of left and right-side inguinal hernias by laparoscopic technique and a right true vocal cord cyst excision.
1.18 In November 2019, a follow-up ENT evaluation of your vocal cords for hoarseness was stable.
1.19 You have no history of tobacco use, exercise regularly, and seldom drink alcohol.
1.20 Your current daily medications include atorvastatin, aspirin, clopidogrel, levothyroxine, and lisinopril.

Why is he not on a beta blocker?

Why is he on clopidogrel when more effective anti-platelet drugs are recommended after placement of a coronary stent?

Listing only "daily" medications could exclude several important compounds that are taken only when symptoms flare or are dosed less frequently than daily. Examples might include colchicine for his gout, pain relievers for his lumbar pain (opiates?!), and any of multiple medication types for his esophageal reflux (antacids, proton-pump inhibitors, ...).

1.21 The most significant event in your recent health was your admission to the Desert Springs Hospital in Las Vegaso Nevada on October 1, 2019.
1.22 You experienced myocardial infarction due to an acute blockage of a coronary artery.
1.23 In the initial hours of your evaluation, you were found to have an elevation of cardiac muscle proteins in your blood accompanied by diminished heart muscle strength and chamber wall motion reduction as determined by echocardiogram.
1.24 You underwent prompt cardiac catheterization with identification of the narrowed segment of the midportion of the left anterior descending coronary artery.
1.25 The narrowed segment was re-opened followed by the placement of two drug-eluting stents, a procedure that is referred to as primary percutaneous coronary intervention (PCI).
1.25b You received standard treatment with medications to improve your heart function and provide antiplatelet therapy required by your stents.
1.26 You were released from the hospital three days later and returned home.
1.27 You have obtained additional consultation with cardiologists in your home state of vermont in November and December 2019 who have closely followed your cardiovascular function with serial echocardiograms and adjustment of your medications.
1.28 Several of the medications you initially required (blood-thinner, beta blocker) were stopped based on your progress.

Stopped B-blocker?

Blood thinner was probably heparin, but one wonders about coumadin for aneurysm, since it would be weird to call out a blood thinner if he didn't go home on it. Home-injected heparin?
1.29 Your heart muscle strength has improved.

This statement sounds favorable, but it may be meaningless because the physician's note does not say how and why the strength improved, or how the strength was measured. The difficulty is that heart muscle strength can improve in two different ways. The first way is for the muscle to get better of its own accord. This is common, especially in the first few days after a heart attack. The second is for the muscle to appear to get stronger when it really does not. This occurs in almost every heart attack patient, after the cardiologist prescribes medication to lower blood pressure. This is best understood by thinking about muscle outside of the heart: If I watched you lifting a 50-pound dumbbell with your arm, and also watched you lift a 5-pound dumbbell, both times not seeing the dumbbell itself, I would think that "looked" stronger lifting the 5-pound weight because your arm moved more quickly and more vigorously. It is the same in cardiology. We look at an echocardiogram to see how the heart muscle is moving after a heart attack, but we cannot see the blood pressure that is opposing that movement. So, if I see that your heart muscle is looking stronger on day 2, it may be because your muscle actually is better, or it may be because I've given you medicines to lower your blood pressure. Sick hearts can be very sensitive to even small changes in blood pressure.

1.30 You have never had symptoms of congestive heart failure.

The physician's note nowhere says that Sanders has been free of signs of heart failure. The distinction is that "symptoms" are feelings that the patient subjectively experiences. "Signs" are objective findings that the physician detects. So, for example, a physician who hears crackling sounds in the patient's lungs via a stethoscope has detected a sign of heart failure. It is not a symptom because the patient is completely unaware of the sounds.

One important symptom of heart failure is breathlessness when attempting to sleep flat. Because Sanders has esophageal reflux [§1.15e], it is possible that he routinely sleeps with his head elevated, and so never attempts to sleep flat.

While reassuring that Sanders never had symptoms of heart failure, it should be remembered that the main symptoms of heart failure emerge during physical exertion. For many heart attack patients (especially those in whom the left anterior descending coronary artery is obstructed [§1.24]), heart function is most compromised in the first day after a heart attack, which is precisely a time during which heart attack patients are confined to bed. (There is an indication of this with Sanders in [§1.29] where his heart function was noted to have improved.) Without physical exertion, the opportunity to experience the symptoms of heart failure is greatly limited.

Given the above criticisms of even a simple, innocuous-sounding statement, it becomes apparent that physician summaries of a complicated illness like myocardial infarction cannot be trusted. There is too much room for ambiguity (at best) or concealment (at worst).
1.31 The heart chamber sizes, wall thickness, estimated pressures, and heart valves are normal.
1.32 Several 24-hour recordings of your heart electrical activity indicated no significant heat rhythm abnormality.

Does this exclude LBBB?

1.33 In December 2019, you underwent a successful graded exercise treadmill examination monitoring your heart function, muscular exertion, and oxygen consumption that indicated a maximal level of exertion to 92% of your predicted heart rate without any evidence of reduced blood flow to your heart or symptoms limiting your exercise performance.
The maximum predicted heart rate for a 78-year-old is 142 beats per minute (equals 220 minus age), so 92% of that is 120 beats per minute.
1.34 Your overall test performance was rated above average compared to a reference population of the same age.

OOPS - NOT HEART ATTACK SURVIVORS. This statement is perfidious. The "reference population" to which the physician's note refers is a population of age-matched heart attack survivors [§2.6]. Although it is a true statement, by leaving the "reference population" undescribed, it is clearly intended to deceive non-physician readers by injecting the descriptor "above average." If a physician is going to write a letter with simple language that is aimed at a general, non-physician audience, then it is incumbent on the physician to take care that the concepts are presented as clearly as the language. That did not happen here, and there can be no appeals that it was merely a stylistic error of prose composition. It was deliberate obfuscation.

Even if the physician had here disclosed that the reference population was heart attack survivors, it would still be an underhanded comparison, for reasons discussed in sentence [§2.6].

1.35 The cardiac exercise physiologist who evaluated your results determined that you are fit to resume vigorous activity without limitation.
1.36 You are in good health currently and you have been engaging vigorously in the rigors of your campaign, travel, and other scheduled activities without any limitation.

Omits the plan for follow-up of the heart attack. How often will he be seeing a physician? Is another stress test to occur? Will his list of medications evolve?

1.37

Dr. Monahan studiously avoids giving his military rank (rear admiral) here and in the letterhead.

These docs use their titles to create aura of objectivity and neutrality, but clearly not so. Have omitted the obvious negatives in effort to minimize electoral threat.

1.x XXXX

Does not mention:

  • Coronary anatomy. (Doesn't even have indication of STEMI vs. NSTEMI)
  • Abnormal aspects of EKG
  • Ejection fraction (with low BP, ejection fraction is higher)
  • He has a fixed wall motion abnormality (per LeWinter letter). Unsaid dx: "ischemic cardiomyopathy"
  • Size of infarct by troponin level not given (Is this still considered valid indication of infarct size?)
  • Why not on beta blocker? Is LBBB a [relative] contra-indication? Asthma? COPD?
  • He may have average exercise tolerance now, but maybe he lost something (i.e. was better before)
  • Was he on beta blockers when stress test performed? (sloppy)
  • Doesn't say why exercise tests stopped (sloppy)
  • This was a cardiopulmonary [metabolic] stress test. Should have reported peak RER.
  • Is there a cardiac rehab. program? [should there be?] [did he complete one?]
  • What's in his carotids?
  • Monahan letter says exercise tolerance is "above average compared to a reference population of the same age." But letter from exercise physiologist says exercise is [merely] average for a non-diseased reference population; is above average only for an age-matched population with "a similar diagnosis" (infarct survivor?)
  • Why did they do cardiopulmonary stress test? Is this now recommended after MI? Should check what the indications are now felt to be.

2.1

This letter, and the next one, is written by a state employee. Has the appearance of a conflict.

2.2 Re: Results of Cardiopulmonary Exercise Tolerance Test

This letter has no date, a small lapse, but it is an unprofessional mark against the letter-writer. As with all elements of a medical record, letters like this are legal documents and must be dated. It is a further suggestion that the author of the letter was not a physician -- i.e. not the person who signed the letter -- because physicians write such letters frequently and have the practice of universal letter-dating drummed into them.

2.3 Mr. Sanders underwent a cardiopulmonary exercise tolerance test on 12/11/2019 as part comprehensive examination at the University of Vermont Medical Center (UVMMC) Cardiac Rehabilitation Program.

Exercise test was 9 - 10 weeks post MI. I think is ok re: waiting time after infarct.

2.4 Cardiopulmonary exercise testing is an important clinical tool to evaluate exercise capacity and predict outcomes in patients with a cardiac condition.
2.5 It provides a comprehensive assessment of the integrative exercise responses involving the pulmonary, cardiovascular and skeletal muscle systems.
2.6 Mr. Sanders was able to exercise to a level that is approximately 50% higher than other men his age with a similar diagnosis [1].

This phrasing is ambiguous. See annotations in Fig. 4 of reference 1 to see the two ways to interpret the sentence.

Article covers CABG, MI, PCI, UAP. Sample skewed to dx not impacting LVEF. Has 20% current or recent smoker, but this did not affect VO2max. 75% on B-blocker.

OOPS - NOT HEART ATTACK SURVIVORS. There is no medical reason to include this statement, because the comparison group is so heterogenous. "Heterogeneous" refers to the fact that all heart attacks are not created equal. At one extreme, heart attacks may go unnoticed by patients (Senator Sanders' heart attack was not small). At the other extreme, some heart attack survivors will become bed-bound (it is pretty easy to exercise 50% better than them). Thus, the so-called "reference population" is really not a reference population at all, because the average exercise ability of the group depends entirely on how many severe heart attacks are included in the group vs. how many small ones are included.
    In this particular case, the heart attack survivors were patients who lived to enter a cardiac rehabilitation program. PRIMARY REFERENCE SAYS EXERCISE TOLERANCE IS EXTREMELY LOW. IT IS UNDERSTANDABLE THAT A PERSON WOULD CITE THEIR OWN WORK ON AN OCCASION WHEN IT IS CERTAIN TO RECEIVE NATIONAL ATTENTION, BUT NOT SURE WHY MONAHAN WENT ALONG WITH IT.

2.7 Compared to otherwise healthy men with no known heart disease, his exercise capacity is average for man his age [2].

Would be interesting to look up, in the article, exactly what that exercise tolerance is.

Typo: "man his age" should be "men his age."
2.8 Mr. Sander's level of fitness would be suggestive of favorable outcomes, from a cardiovascular perspective, going forward.
Typo: Sander's should be Sanders'.
2.9 According to Philip Ades, MD, Cardiologist, Director of Preventive Cardiology at UVMMC, "Mr. Sanders is more than fit enough to pursue vigorous activities and an occupation that requires stamina and an ability to handle a great deal of stress."

"According to" --> further suggestion

Am not sure this ETT informs ability to handle stress.

Is saying that the presidency requires no more stamina than a normal 78yo man can muster.

2.10
2.11

Physiologist didn't sign, but it appears he wrote the letter.

2.12 1. Ades PA, Savage PD, Brawner CA, Lyon CE, Ehrman JK, Bunn JY, Keteyian SJ.Aerobic capacity in patients entering cardiac rehabilitation. Circulation. 2006 Jun 13;113.33):2706-12. Epub 2006 Jun 5

75% of subjects on beta blockers

Typographical error in spacing.
2.13 2. Kaminsky LA, Arena R, Myers J. Reference Standards for Cardiorespiratory Fitness Measured With Cardiopulmonary Exercise Testing: Data From the Fitness Registry and the Importance of Exercise National Database.Mayo Clin Proc. 2015 Nov;90(11):1515-23. doi: 10.1016/j.mayocp.2015.07.026. Epub 2015 Oct 5.
Typographical error in spacing.

3.1

This letter, and the previous one, is written by a state employee. Has the appearance of a conflict.

3.2 December 30, 2019
3.3 To whom it may concern:
3.4 Following is my assessment of the current medical status of my patient, Senator Bernard Sanders.
3.5 Senator Sanders hasmade an uneventful recovery from the heart attack he suffered in Las Vegas, October 1, 2019.
3.6 He received prompt and effective stent treatment to restore blood flow to his heart muscle.
3.7 While he did suffer modest heart muscle damage, he has been doing very well since.
3.8 He is currently entirely asymptomatic, his heart function is stable and well-preserved, his blood pressure and heart rate are in optimal ranges, he is getting regular exercise and his exercise tolerance, based on quantitative, cardiopulmonary exercise testing, is well above average.

He gets it wrong, too, like Monahan did: reference population per Ades is coronary population. Plus, LeWinter is just plain wrong when he says "well above average" -- the average person in the USA is in their 30s. So either LeWinter is ill-informed, is sloppy in his language (but look at all those credentials!), or has a secondary aim with his language, i.e. trying to put a shine on the situation.

3.9 He is receiving several medications that are routinely prescribed after a heart attack and stenting procedure.
3.10 At this point, I see no reason he cannot continue campaigning without limitation and, should he be elected, I am confident he has the mental and physical stamina to fully undertake the rigors of the Presidency.
3.11
3.x

Now, maybe the criticisms given above will themselves be criticized as hyper-picky and therefore unreasonable. But they are completely valid according to the words that are (or are not) in the officially released documents. If there is a belief that this critique is hyper-picky, people should realize that this is a problem of the doctors' own making. They released English-language summaries of the primary data. Had they released the data itself, a lot of the ambiguity and uncertainty I've identified in their words would have been eliminated. But they chose not to release the primary data. By not releasing it, they are asking us to trust them, but with their obviously slanted and incomplete reports they have shown themselves not to be honest brokers. They could have been honest brokers. In their professional practices, they all have long experience writing letters that clearly and unambiguously describe the medical condition of their patients. It is essential to the successful practice of internal medicine and especially cardiology. The physicians have chosen not to write such letters to the American people. It's not entirely the physicians' fault. They can disclose only what their patient allows them to disclose (well, not Dr. Monahan, since he was writing to the patient). But there are ways to write letters that do not disclose information while making it clear that information is being held back. ("Among the findings on cardiac catheterization...") These physicians have an opinion on their patient's suitability to the job of being president. That is fine. They can certainly write whatever they truthfully believe in their professional judgment. But as soon as they go beyond that sentence or two and start providing data to support their opinions, they have to be intellectually honest. They have to provide data that is both pro- and con- to their stated opinion. If they provide only the pro- information, that is not intellectually honest and is, moreover, unprofessional. Yes, they can advocate for their patient (as any good physician would do) but it must be done honestly & professionally.

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